Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?

Immune checkpoint receptors (IC) positively or negatively regulate the activation of the host immune response, preventing unwanted reactions against self-healthy tissues. In recent years the term IC has been mainly used for the inhibitory ICs, which are critical to control Natural Killer (NK) and Cy...

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Principais autores:	Pilar M. Lanuza, Cecilia Pesini, Maykel A. Arias, Carlota Calvo, Ariel Ramirez-Labrada, Julian Pardo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-01-01
coleção:	Frontiers in Immunology
Assuntos:	NK cell adoptive cell therapy T cell immune check point cancer
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.03010/full
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