Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients

To investigate whether different forms of α-synuclein (α-syn) proteins can induce inflammation and activate the NLRP3 inflammasome, we stimulated with monomeric or aggregated α-syn peripheral blood mononuclear cells of Parkinson disease (PD) patients and age- and sex-matched healthy controls (HC). A...

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Detalhes bibliográficos

Principais autores:	Federica Piancone, Marina Saresella, Francesca La Rosa, Ivana Marventano, Mario Meloni, Jorge Navarro, Mario Clerici
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-03-01
coleção:	Frontiers in Neuroscience
Assuntos:	Parkinson’s disease α-synuclein inflammation inflammasome cytokines
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2021.639646/full
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