p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion.

Tumor suppressor SMAR1 interacts and stabilizes p53 through phosphorylation at its serine-15 residue. We show that SMAR1 transcription is regulated by p53 through its response element present in the SMAR1 promoter. Upon Doxorubicin induced DNA damage, acetylated p53 is recruited on SMAR1 promoter th...

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Principais autores:	Kamini Singh, Devraj Mogare, Ramprasad Obula Giridharagopalan, Rajinikanth Gogiraju, Gopal Pande, Samit Chattopadhyay
格式:	Artigo
语言:	Inglês
出版:	Public Library of Science (PLoS) 2007-01-01
丛编:	PLoS ONE
在线阅读:	http://europepmc.org/articles/PMC1924604?pdf=render
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