The Transcription Factor Function of Parkin: Breaking the Dogma

PRKN (PARK2) is a key gene involved in both familial and sporadic Parkinson’s disease that encodes parkin (PK). Since its discovery by the end of the 90s, both functional and more recently, structural studies led to a consensual view of PK as an E3 ligase only. It is generally considered that this f...

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Κύριοι συγγραφείς:	Cristine Alves da Costa, Eric Duplan, Lila Rouland, Frédéric Checler
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2019-01-01
Σειρά:	Frontiers in Neuroscience
Θέματα:	Parkinson’s disease parkin gene control DNA binding ubiquitin ligase structure
Διαθέσιμο Online:	https://www.frontiersin.org/article/10.3389/fnins.2018.00965/full
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