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GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux

Glutathione S-transferase P1(GSTP1) is known for its transferase and detoxification activity. Based on disease-phenotype genetic associations, we found that GSTP1 might be associated with bone mineral density through Mendelian randomization analysis. Therefore, this study was performed both in vitro...

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Main Authors: Xiaoxiao Ji, Jianqiao Hong, Weinan Yang, Minjun Yao, Jie Wang, Guangyao Jiang, Yibo Wang, Congsun Li, Jiyan Lin, Haochen Mou, Chaozhong Li, Sihao Li, Yazhou Chen, Minming Shi, Wei Wang, Fei Lu, Haobo Wu, Xiang Zhao, Yiying Qi, Shigui Yan
Format: Artigo
Language:Inglês
Published: Elsevier 2023-05-01
Series:Redox Biology
Subjects:
GSTP1
S-glutathionylation
Autophagic flux
Osteoclastogenesis
Pik3r1/AKT/mTOR
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000368
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