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Cognitive benefits of folic acid supplementation during pregnancy track with epigenetic changes at an imprint regulator

Abstract Background The human ZFP57 gene is a major regulator of imprinted genes, maintaining DNA methylation marks that distinguish parent-of-origin-specific alleles. DNA methylation of the gene itself has shown sensitivity to environmental stimuli, particularly folate status. However, the role of...

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Principais autores: L. Hilman, M. Ondičová, A. Caffrey, M. Clements, C. Conway, M. Ward, K. Pentieva, R. E. Irwin, H. McNulty, C. P. Walsh
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-12-01
coleção:BMC Medicine
Assuntos:
DNA methylation
ZFP57
Methylation quantitative trait loci
Linkage disequilibrium
Folic acid
Acesso em linha:https://doi.org/10.1186/s12916-024-03804-2
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