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SHIELD study: a multicenter, open-label, single-arm trial to evaluate the safety, pharmacokinetics and antiviral activity of fostemsavir in combination with optimized background therapy (OBT) in children and adolescents with HIV who are failing their current combination antiretroviral therapy (cART) and have dual- or triple-class antiretroviral (ARV) resistance

Abstract Background Multi-drug resistant HIV-1 is a growing global concern in children, highlighting the need for new antiretroviral drugs. Fostemsavir, recently approved for adults with multi-drug resistant HIV-1 and limited treatment options, has not yet been evaluated in the pediatric population....

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Principais autores: Carlos Grasa, Nicolas Salvadori, Alessandra Nardone, Kanchana Than-in-at, Alicia Koblansky, Chris Parry, Nilay Thakkar, Marcia Wang, Carlo Giaquinto, Pablo Rojo, Tim R. Cressey
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-02-01
coleção:BMC Infectious Diseases
Assuntos:
Fostemsavir
Antiretrovirals
HIV
Multi-drug resistance
Children
Adolescents
Acesso em linha:https://doi.org/10.1186/s12879-026-12806-9
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