Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis

Abstract Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-inhibitory proteins (cFLIP) assemble through death-effector domains (DEDs), directing death receptor signaling towards cell survival or apoptosis. Understanding their three-dimensional regulatory mechanism has...

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Detalhes bibliográficos

Principais autores:	Chao-Yu Yang, Chia-I Lien, Yi-Chun Tseng, Yi-Fan Tu, Arkadiusz W. Kulczyk, Yen-Chen Lu, Yin-Ting Wang, Tsung-Wei Su, Li-Chung Hsu, Yu-Chih Lo, Su-Chang Lin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-05-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-47990-2
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