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Investigating the role of GLUL as a survival factor in cellular adaptation to glutamine depletion via targeted stable isotope resolved metabolomics

Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance. The application of ‟targeted stable isotope resolved metabolomics” allowed to directly measure the activity of glutamine synthetase i...

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Principais autores: Șafak Bayram, Yasmin Sophiya Razzaque, Sabrina Geisberger, Matthias Pietzke, Susanne Fürst, Carolina Vechiatto, Martin Forbes, Guido Mastrobuoni, Stefan Kempa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-08-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
targeted stable isotope resolved metabolomics
GLUL
nucleotide biosynthesis
glutamine addiction
cancer metabolism
glutamine synthetase
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2022.859787/full
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