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Integrating multi-omics data revealing LIMK1 as a metastatic biomarker in LUAD patients with brain metastasis

Abstract Background Lung adenocarcinoma (LUAD) is a major subtype of lung cancer that frequently develops brain metastases. Tumor heterogeneity substantially complicates disease management, and reliable biomarkers for metastatic progression remain lacking. LIM domain kinase 1 (LIMK1), a key regulato...

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Principais autores: Changqing Yang, Jianjian Ying, Cangchang Shi, Linyue Hai, Guixin Wang, Yingxi Li, Yao Tian, Jinxian He, Keyun Zhu, Jing Feng
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-03-01
Series:Cancer Cell International
Assuntos:
lung adenocarcinoma
brain metastasis
tumor heterogeneity
LIMK1
multi-omics
Acceso en liña:https://doi.org/10.1186/s12935-026-04278-3
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