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Molecular basis of human trace amine-associated receptor 1 activation

Abstract The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its tractability as a drug target, its molecular mechanisms of activation remain unclear. Moreover...

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Autori principali: Gregory Zilberg, Alexandra K. Parpounas, Audrey L. Warren, Shifan Yang, Daniel Wacker
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-01-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-023-44601-4
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