Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2

Abstract Background Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was ap...

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Xehetasun bibliografikoak

Egile Nagusiak:	Dasom Kim, Dongwha Min, Joohee Kim, Min Jung Kim, Yerim Seo, Byung Hwa Jung, Seung‑Hae Kwon, Hyunju Ro, Seoee Lee, Jason K. Sa, Ji-Yun Lee
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2023-12-01
Saila:	Journal of Experimental & Clinical Cancer Research
Gaiak:	KRAS mutation GFPT2 HBP Macropinocytosis Nutlin-3a Methuosis
Sarrera elektronikoa:	https://doi.org/10.1186/s13046-023-02922-8
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