Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans

We describe a simple bioinformatics method for biomarker discovery that is based on the analysis of global transcript levels in a population of inbred mouse strains showing variation for disease-related traits. This method has advantages such as controlled environment and accessibility to heart and...

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Main Authors:	Liang-Yu Lin, Sunny Chun Chang, Jim O’Hearn, Simon T. Hui, Marcus Seldin, Pritha Gupta, Galyna Bondar, Mario Deng, Raimo Jauhiainen, Johanna Kuusisto, Markku Laakso, Janet S. Sinsheimer, Arjun Deb, Christoph Rau, Shuxun Ren, Yibin Wang, Aldons J. Lusis, Jessica J. Wang, Adriana Huertas-Vazquez
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2018-11-01
Series:	G3: Genes, Genomes, Genetics
Subjects:	Biomarkers, GPNMB Heart failure Systems genetics, Transcriptome
Online Access:	http://g3journal.org/lookup/doi/10.1534/g3.118.200655
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