Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II

Abstract The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the pericentromere in meiosis II. In mammalian oocytes, separase is tightly controlled during the hours-long prometaphase...

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Detalhes bibliográficos

Principais autores:	Safia El Jailani, Damien Cladière, Elvira Nikalayevich, Sandra A Touati, Vera Chesnokova, Shlomo Melmed, Eulalie Buffin, Katja Wassmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2025-08-01
coleção:	The EMBO Journal
Assuntos:	Cohesin Protection Kinetochore Individualization Meiosis Oocytes Separase Inhibition
Acesso em linha:	https://doi.org/10.1038/s44318-025-00522-0
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