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Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling

Yeast helicase Prp28 promotes the first step of spliceosome remodeling. By placing a photoactivatable unnatural amino acid in Prp28, the authors capture Prp28 in action revealing its dynamic interactions and cofactor Npl3.

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Principais autores: Fu-Lung Yeh, Shang-Lin Chang, Golam Rizvee Ahmed, Hsin-I Liu, Luh Tung, Chung-Shu Yeh, Leah Stands Lanier, Corina Maeder, Che-Min Lin, Shu-Chun Tsai, Wan-Yi Hsiao, Wei-Hau Chang, Tien-Hsien Chang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2021-05-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-021-23459-4
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