From disruption to remodeling: the evolution and therapeutic prospects of Neuroimmune Regulatory Circuitry after ischemic stroke

Ischemic stroke (IS) is a leading cause of death and long-term disability globally, and the efficacy of current reperfusion therapies is limited, highlighting a significant unmet clinical need. This review reconceptualizes IS not as a mere focal brain injury but as a systemic disease driven by the c...

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Principais autores:	Yikun Gao, Qing Chen, Rui Tao, Wenrui Han, Zhanyong Zhu, Lijuan Gu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
coleção:	Frontiers in Immunology
Assuntos:	ischemic stroke Neuroimmune Regulatory Circuitry neuroimmunology sympathetic nervous system vagus nerve
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1702245/full
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