Mechanical Stimulation Protects Against Chondrocyte Pyroptosis Through Irisin-Induced Suppression of PI3K/Akt/NF-κB Signal Pathway in Osteoarthritis

Irisin, a myokine secreted by muscle during physical exercise, is known to have biological activities in different cell types. Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shuangshuo Jia, Yue Yang, Yishu Bai, Yingliang Wei, He Zhang, Yicheng Tian, Jiabao Liu, Lunhao Bai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-03-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	irisin osteoarthritis exercise PI3K/Akt/NF-κB pyroptosis chondrocyte
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2022.797855/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!