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Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification

Coronavirus disease 2019 is a kind of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism whereby SARS-CoV-2 invades host cells remains poorly understood. Here we used SARS-CoV-2 pseudoviruses to infect human angiotensin-converting enzyme 2...

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Principais autores: Xiaowei Li, Wenhua Zhu, Meiyang Fan, Jing Zhang, Yizhao Peng, Fumeng Huang, Nan Wang, Langchong He, Lei Zhang, Rikard Holmdahl, Liesu Meng, Shemin Lu
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science (AAAS) 2021-01-01
coleção:Computational and Structural Biotechnology Journal
Assuntos:
SARS-CoV-2
Endocytosis
Endosomal acidification
Lipid rafts
Cholesterol
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2001037021001070
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