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Single cell transcriptome signatures and cell-cell interactions associated with sarcoidosis in lung immune cell populations

BackgroundSarcoidosis is a complex, multi-system granulomatous disease characterized by immune dysregulation and chronic inflammation, primarily affecting the lungs. To identify cell specific molecular changes associated with sarcoidosis development and progression, we aimed to characterize cellular...

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Principais autores: Camille M. Moore, Shu-Yi Liao, Cheyret Wood, Arunangshu Sarkar, Jonathan H. Cardwell, Kristyn MacPhail, Margaret M. Mroz, Christina Riley, Kara Mould, Clara I. Restrepo, Li Li, Lisa A. Maier, Ivana V. Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Immunology
Assuntos:
lung macrophages
pulmonary sarcoidosis
sarcoidosis progression
single cell molecular profiles
transcriptomics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1765314/full
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