Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh syndrome mice

Abstract Leigh syndrome (LS) is a complex, genetic mitochondrial disorder defined by neurodegenerative phenotypes with pediatric manifestation. However, recent clinical studies report behavioral phenotypes in human LS patients that are more reminiscent of neurodevelopmental delays. To determine if d...

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Bibliografski detalji

Glavni autori:	Sahitya Ranjan Biswas, Porter L Tomsick, Colin Kelly, Brooke A Lester, Julia P Milner, Sara N Henry, Yairis Soto, Samantha Brindley, Nicole DeFoor, Paul D Morton, Alicia M Pickrell
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2025-12-01
Serija:	EMBO Molecular Medicine
Teme:	Leigh Syndrome Postnatal Neurogenesis Neural Stem Cells Subventricular Zone Corpus Callosum
Online pristup:	https://doi.org/10.1038/s44321-025-00367-4
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