Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcN...

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Hlavní autoři:	Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	The Royal Society 2019-11-01
Edice:	Open Biology
Témata:	o-glcnacylation crmp2 crosstalk cognitive function
On-line přístup:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190192
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