RNA binding proteins PTBP1 and HNRNPL regulate CFTR mRNA decay
Background: CFTR nonsense alleles generate negligible CFTR protein due to the nonsense mutation: 1) triggering CFTR mRNA degradation by nonsense-mediated mRNA decay (NMD), and 2) terminating CFTR mRNA translation prematurely. Thus, people with cystic fibrosis (PwCF) who carry nonsense alleles cannot...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2023-11-01
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| Colección: | Heliyon |
| Materias: | |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2405844023094896 |
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