CISD2 ensures adequate ER-mitochondrial coupling, critically supporting mitochondrial function in neurons

Abstract Loss of Cisd2, an iron-sulfur cluster transfer protein, results in type 2 Wolfram syndrome (WS2), a disorder associated with severe impacts on pancreatic β cell and neuronal functions. Cisd2 has been implicated in regulating intracellular Ca2+ signaling. However, the molecular basis and cel...

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Главные авторы:	Jens Loncke, Ian de Ridder, Rita La Rovere, Annika Vaarmann, Guizhen Fan, Karan Ahuja, Irina Serysheva, Catherine Verfaillie, Martijn Kerkhofs, Jan B. Parys, Allen Kaasik, Geert Bultynck, Tim Vervliet
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-11-01
Серии:	Acta Neuropathologica Communications
Предметы:	Wolfram syndrome Neurodegeneration Apoptosis Ca2+ signaling Cisd2 ER-mitochondria contact sites
Online-ссылка:	https://doi.org/10.1186/s40478-025-02132-7
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