Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation
Tumor cells undergo extensive metabolic reprogramming during malignant proliferation, with serine—a key nonessential amino acid—playing multiple roles in tumor metabolism. To maintain high serine levels, tumor cells upregulate phosphoglycerate dehydrogenase to enhance endogenous synthesis and concur...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2025-12-01
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| Serie: | Frontiers in Oncology |
| Soggetti: | |
| Accesso online: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1669565/full |
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