Biological evaluation of semi-synthetic isoindolinone isomers produced by Stachybotrys chartarum

The filamentous fungus Stachybotrys chartarum is rich in meroterpenoid secondary metabolites, some of which carry o-dialdehyde moieties, which are readily derivatized to isoindolinones by addition of primary amines. The structural diversity of phenylspirodrimanes, in particular, is linked to a wide...

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Autors principals:	Alica Fischle, Ulrich Schreiber, Viola Haupt, Felix Schimang, Lina Schürmann, Matthias Behrens, Florian Hübner, Melanie Esselen, Dmitrii V. Kalinin, Svetlana A. Kalinina
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2024-11-01
Col·lecció:	Frontiers in Fungal Biology
Matèries:	semi-synthesis regioisomerism Stachybotrys genotoxicity biological activity hepatic metabolism
Accés en línia:	https://www.frontiersin.org/articles/10.3389/ffunb.2024.1494795/full
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