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BIDCell: Biologically-informed self-supervised learning for segmentation of subcellular spatial transcriptomics data

Abstract Recent advances in subcellular imaging transcriptomics platforms have enabled high-resolution spatial mapping of gene expression, while also introducing significant analytical challenges in accurately identifying cells and assigning transcripts. Existing methods grapple with cell segmentati...

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I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Xiaohang Fu, Yingxin Lin, David M. Lin, Daniel Mechtersheimer, Chuhan Wang, Farhan Ameen, Shila Ghazanfar, Ellis Patrick, Jinman Kim, Jean Y. H. Yang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2024-01-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-023-44560-w
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