Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

Indoleamine 2,3-dioxygenase (IDO) has been described as a major mechanism of immunosuppression in tumors, though the mechanisms of this are poorly understood. Here, we find that expression of IDO by tumor cells results in aggressive tumor growth and resistance to T-cell-targeting immunotherapies. We...

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Bibliografiske detaljer

Principais autores:	Rikke B. Holmgaard, Dmitriy Zamarin, Yanyun Li, Billel Gasmi, David H. Munn, James P. Allison, Taha Merghoub, Jedd D. Wolchok
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2015-10-01
Serier:	Cell Reports
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124715009900
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