Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. PS1/γ-secretase mediates axon growth by inhibiting Rho...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Míriam Javier-Torrent, Sergi Marco, Daniel Rocandio, Maria Pons-Vizcarra, Peter W Janes, Martin Lackmann, Joaquim Egea, Carlos A Saura
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	eLife Sciences Publications Ltd 2019-10-01
Sarja:	eLife
Aiheet:	PS/g-secretase axon growth EphA/ephrin signaling neurons
Linkit:	https://elifesciences.org/articles/43646
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