Mechanism of Gzma‐mediated GEF‐H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis

Abstract Background Sepsis‐induced intestinal injury is a severe complication associated with dysfunction affecting multiple organ systems and a significantly elevated risk of death. Intestinal barrier dysfunction plays a central role, but the underlying molecular pathways remain incompletely unders...

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Principais autores:	Zexing Lin, Haiyang Jiang, Chujun Ni, Liting Deng, Huan Yang, Runnan Wang, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Bo Liao, Juanhan Liu, Weizhen Li, Jiaxin Yang, Yue Chao, Haiqing Liu, Xiuwen Wu, Jianan Ren, Yun Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2026-04-01
Series:	Clinical and Translational Medicine
Assuntos:	Epothilone A Epithelial integrity Gzma (granzyme A) GEF‐H1 Intestinal barrier dysfunction RhoA/ROCK signalling
Acceso en liña:	https://doi.org/10.1002/ctm2.70651
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