Benchmarking mouse contamination removing protocols in patient-derived xenografts genomic profiling

Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. Genomic and transcriptomic profiling of PDXs are inevitably contaminated by sequencing reads originated from mouse cells. Here, we examine the impact of mouse read contamination on RNA sequencing (RNAseq), Whole Exom...

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Hlavní autoři:	Mukund Bhandari, Funan He, Anna Rogojina, Fuyang Li, Yi Zou, Jing Jiang, Zhao Lai, Peter Houghton, Raushan T. Kurmasheva, Yidong Chen, Xiaojing Wang, Siyuan Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-04-01
Edice:	npj Precision Oncology
On-line přístup:	https://doi.org/10.1038/s41698-025-00902-z
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