C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

ABSTRACT Acinetobacter baumannii has become a major nosocomial pathogen, as it is often multidrug-resistant, which results in infections characterized by high mortality rates. The bacterium achieves high levels of resistance to β-lactam antibiotics by producing β-lactamases, enzymes which destroy th...

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Autori principali:	Nichole K. Stewart, Marta Toth, Maha A. Alqurafi, Weirui Chai, Thu Q. Nguyen, Pojun Quan, Mijoon Lee, John D. Buynak, Clyde A. Smith, Sergei B. Vakulenko
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2022-06-01
Serie:	mBio
Soggetti:	β-lactamase OXA-23 Acinetobacter inhibitor carbapenem crystal structure
Accesso online:	https://journals.asm.org/doi/10.1128/mbio.00367-22
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