Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Abstract Mild replication interference is a consolidated strategy for cancer chemotherapy. Tolerance to mild replication stress (RS) relies on active fork slowing, mediated by transient fork reversal and RECQ1-assisted restart, and modulated by PARP1 and nuclear architectural components via yet-elus...

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Detalhes bibliográficos

Principais autores:	Veronica Cherdyntseva, Joanna Paulson, Daniel González-Acosta, Patricia Ubieto-Capella, Melani Rodrigues, Moses Aouami, Selin Adakli, Jean-Philippe Gagné, Collin Bakker, Guy G. Poirier, Nitika Taneja, Massimo Lopes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-66098-9
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