TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease

Paraoxonase 1 (PON1) activity is consistently predictive of vascular disease, although the genotype at four functional PON1 polymorphisms is not. To address this inconsistency, we investigated the role of all common PON1 genetic variability, as measured by tagging single-nucleotide polymorphisms (ta...

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Detalhes bibliográficos

Principais autores:	Christopher S. Carlson, Patrick J. Heagerty, Thomas S. Hatsukami, Rebecca J. Richter, Jane Ranchalis, Julieann Lewis, Tamara J. Bacus, Laura A. McKinstry, Gerard D. Schellenberg, Mark Rieder, Deborah Nickerson, Clement E. Furlong, Alan Chait, Gail P. Jarvik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2006-05-01
coleção:	Journal of Lipid Research
Assuntos:	paraoxonase carotid artery disease LDL oxidation haplotype genotype tagging single-nucleotide polymorphism
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520332508
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