Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

ABSTRACT Aberrant deposition of β‐amyloid (Aβ) and hyperphosphorylated tau, along with neuroinflammation, are key drivers of Alzheimer's disease (AD) pathology. Here, we identify ramalin, a natural antioxidant, as a promising therapeutic agent that alleviates AD pathology by modulating β‐site APP cl...

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Principais autores:	Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo
格式:	Artigo
語言:	Inglês
出版:	Wiley 2026-01-01
叢編:	MedComm
主題:	Alzheimer's disease BACE1 HDAC6 NLRP3 (NLR family pyrin domain containing 3) inflammasome ramalin
在線閱讀:	https://doi.org/10.1002/mco2.70518
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