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Modulation of E-Cadherin Function through the AmotL2 Isoforms Promotes Ameboid Cell Invasion

The spread of tumor cells and the formation of distant metastasis remain the main causes of mortality in cancer patients. However, the mechanisms governing the release of cells from micro-environmental constraints remain unclear. E-cadherin negatively controls the invasion of epithelial cells by mai...

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Main Authors: Aravindh Subramani, Weiyingqi Cui, Yuanyuan Zhang, Tomas Friman, Zhihai Zhao, Wenmao Huang, Pedro Fonseca, Weng-Onn Lui, Vani Narayanan, Justyna Bobrowska, Małgorzata Lekka, Jie Yan, Daniel E. Conway, Lars Holmgren
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
p60AmotL2
AmotL2
E-cadherin
actin
nuclear lamina
mechanotransduction
Online Access:https://www.mdpi.com/2073-4409/12/13/1682
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