Generation of three isogenic, gene-edited iPSC lines carrying the APOE-Christchurch mutation into the three common APOE variants: APOE2Ch, APOE3Ch and APOE4Ch

Late-onset Alzheimer’s disease (AD) has become the paradigm of a non-mendelian complex neurodegenerative disease, for which a major genetic determinant is known, the APOE locus. A rare APOE variant named Christchurch (APOEch) yielding a missense mutation from Arginine to Serine at amino acid 136, ha...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Mansour Haidar, Benjamin Schmid, Agustín Ruiz, Andreas Ebneth, Alfredo Cabrera-Socorro
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2024-06-01
Serija:	Stem Cell Research
Online dostop:	http://www.sciencedirect.com/science/article/pii/S1873506124001120
Oznake:	Označite Brez oznak, prvi označite!