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Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway.

Osteoprotegerin (OPG) is known to inhibit differentiation and activation of osteoclasts (OCs) by functioning as a decoy receptor blocking interactions between RANK and RANKL. However, the exact role of OPG in the survival/apoptosis of OCs remains unclear. OPG caused increased rates of apoptosis of b...

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Principais autores: Wei Liu, Chao Xu, Hongyan Zhao, Pengpeng Xia, Ruilong Song, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Yan Yuan, Zongping Liu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2015-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4646684?pdf=render
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