Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis

Abstract Background The integrin VLA-4 (α4β1) plays an important role in leukocyte trafficking. This study investigated the efficacy of a novel topical α4β1 integrin inhibitor (GW559090, GW) in a mouse model for non-infectious posterior uveitis (experimental autoimmune uveitis; EAU) and its effect o...

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Detalhes bibliográficos

Principais autores:	Yi Hsing Chen, Malihe Eskandarpour, Xiaozhe Zhang, Grazyna Galatowicz, John Greenwood, Sue Lightman, Virginia Calder
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-02-01
coleção:	Journal of Neuroinflammation
Assuntos:	Integrin (α4β1 VLA-4) Uveitis Experimental autoimmune uveitis Leukocyte migration Th17 cells
Acesso em linha:	https://doi.org/10.1186/s12974-021-02080-8
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