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Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival

Summary: Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Mice lacking H2A.Z in GABAergic neurons or Purkinje cel...

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Principais autores: Christopher Lowden, Aren Boulet, Nicholas A. Boehler, Shavanie Seecharran, Julian Rios Garcia, Nicholas J. Lowe, Jiashu Liu, Jonathan L.K. Ong, Wanzhang Wang, Lingfeng Ma, Arthur H. Cheng, Adriano Senatore, D. Ashley Monks, Bao-hua Liu, Scot C. Leary, Hai-Ying Mary Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-09-01
Serier:Cell Reports
Fag:
neurodegeneration
histone variants
H2A.Z
mitochondria
neurons
cerebellar ataxia
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124721011517
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