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Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-resolution DNA methylation (mC) sequencing. We foun...

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Principais autores: Chongyuan Luo, Qian Yi Lee, Orly Wapinski, Rosa Castanon, Joseph R Nery, Moritz Mall, Michael S Kareta, Sean M Cullen, Margaret A Goodell, Howard Y Chang, Marius Wernig, Joseph R Ecker
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2019-01-01
coleção:eLife
Assuntos:
DNA methylation
epigenomics
epigenetics
reprogramming
transdifferentiation
neuron
Acesso em linha:https://elifesciences.org/articles/40197
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