Promising synergistic interactions and mixture optimization of safranal, crocin, and crocetin from Moroccan Crocus sativus L. with enhanced antimicrobial activity

This study explores the antimicrobial activity of three principal bioactive constituents of Crocus sativus L.—safranal, crocin, and crocetin—using a simplex-centroid mixture design to evaluate their individual and synergistic effects. Twelve formulations were tested against Staphylococcus aureus, Es...

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Principais autores:	Abdellah Baraich, Ibrahim Sadougui, Amine Elbouzidi, Mounir Haddou, Mohamed Taibi, Abdessamad Beraich, Fatima Zahrae El Moussaoui, Omer M. Almarfadi, Ramzi A. Mothana, Mohammed F. Hawwal, Abdeslam Asehraou, Mohamed Addi, François Mesnard, Bassem Jaouadi, Ennouamane Saalaoui
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-02-01
coleção:	Frontiers in Pharmacology
Assuntos:	antimicrobial activity crocetin crocin Crocus sativus L. minimum inhibitory concentration mixturedesign
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1734075/full
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