HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles

HIV-Nef activates the myeloid cell-typical tyrosine kinase Hck, but its molecular role in the viral life cycle is not entirely understood. We found that HIV plasma extracellular vesicles (HIV pEV) containing/10 proteases and Nef also harbor Hck, and analyzed its role in the context of HIV pEV secret...

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Главные авторы:	J.-H. Lee, C. Ostalecki, Z. Zhao, T. Kesti, H. Bruns, B. Simon, T. Harrer, K. Saksela, A.S. Baur
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2018-02-01
Серии:	EBioMedicine
Предметы:	Hck Chronic HIV infection Nef ADAM17 Plasma extracellular vesicles Liver Hepatocytes Myeloid cells
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2352396418300045
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