Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

During obesity, adipose tissue macrophages (ATMs) adopt a metabolically activated (MMe) phenotype. However, the functions of MMe macrophages are poorly understood. Here, we combine proteomic and functional methods to demonstrate that, in addition to potentiating inflammation, MMe macrophages promote...

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Principais autores:	Brittney R. Coats, Kelly Q. Schoenfelt, Valéria C. Barbosa-Lorenzi, Eduard Peris, Chang Cui, Alexandria Hoffman, Guolin Zhou, Sully Fernandez, Lijie Zhai, Ben A. Hall, Abigail S. Haka, Ajay M. Shah, Catherine A. Reardon, Matthew J. Brady, Christopher J. Rhodes, Frederick R. Maxfield, Lev Becker
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2017-09-01
Series:	Cell Reports
Assuntos:	macrophage obesity inflammation insulin resistance adipocyte metabolic activation
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124717312561
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