Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation
Abstract Background Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the initiation of silencing by XIST have focussed on mouse models, so the do...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BMC
2022-02-01
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| Edice: | Epigenetics & Chromatin |
| Témata: | |
| On-line přístup: | https://doi.org/10.1186/s13072-022-00438-7 |
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