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Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response

Mismatch repair proteins modulate the cytotoxicity of several chemotherapeutic agents. We have recently proposed a “death conformation” of the MutS homologous proteins that is distinguishable from their “repair conformation.” This conformation can be induced by a small molecule, reserpine, leading...

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Principais autores: Aksana Vasilyeva, Jill E. Clodfelter, Michael J. Gorczynski, Anthony R. Gerardi, S. Bruce King, Freddie Salsbury, Karin D. Scarpinato
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2010-01-01
Series:Journal of Nucleic Acids
Acceso en liña:http://dx.doi.org/10.4061/2010/162018
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