Discovery of an Experimental Model of Unicuspid Aortic Valve

Background The epithelial growth factor receptor family of tyrosine kinases modulates embryonic formation of semilunar valves. We hypothesized that mice heterozygous for a dominant loss‐of‐function mutation in epithelial growth factor receptor, which are EgfrVel/+ mice, would develop anomalous aorti...

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Bibliografiske detaljer

Principais autores:	Robert M. Weiss, Yi Chu, Robert M. Brooks, Donald D. Lund, Justine Cheng, Kathy A. Zimmerman, Melissa K. Kafa, Phanicharan Sistla, Hardik Doshi, Jian Q. Shao, Ramzi N. El Accaoui, Catherine M. Otto, Donald D. Heistad
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wiley 2018-07-01
Serier:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Fag:	aortic valve aortic valve regurgitation aortic valve stenosis
Online adgang:	https://www.ahajournals.org/doi/10.1161/JAHA.117.006908
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