Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines
<p>Abstract</p> <p>Background</p> <p>Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone.</p> <p>Methods</p> <p>In th...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2013-02-01
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| Serie: | Cancer Cell International |
| Soggetti: | |
| Accesso online: | http://www.cancerci.com/content/13/1/11 |
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