Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis

Abstract Background AXIN1 is a central regulatory hub of many oncogenic pathways in colorectal cancer (CRC). As the main scaffold protein and least abundant component of the beta-catenin destruction complex, changes in AXIN1 levels tightly control Wnt signaling activity. How other cancer pathways be...

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Hlavní autoři:	Nachiyappan Venkatachalam, Li Wang, Niyumi Muthukumarana, Robert Ihnatko, Jeroen Krijgsveld, Olga Skabkina, Antonia Leipertz, Yubin Chen, Ping Sui, Qing Zheng, Panpan Tong, Xi Liu, Arnaud Descot, Matthias Schewe, Gabriele Diamante, Rene Jackstadt, Christoph Brochhausen, Johannes Betge, Kim Boonekamp, Michael Boutros, Georg Stoecklin, Matthias Ebert, Johanna Schott, Tianzuo Zhan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Cell Communication and Signaling
Témata:	Ras-MAPK Wnt AXIN1 MEK inhibitor Colorectal cancer Destruction complex
On-line přístup:	https://doi.org/10.1186/s12964-026-02963-4
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