Optogenetic Stimulation Using Anion Channelrhodopsin (GtACR1) Facilitates Termination of Reentrant Arrhythmias With Low Light Energy Requirements: A Computational Study

Optogenetic defibrillation of hearts expressing light-sensitive cation channels (e.g., ChR2) has been proposed as an alternative to conventional electrotherapy. Past modeling work has shown that ChR2 stimulation can depolarize enough myocardium to interrupt arrhythmia, but its efficacy is limited by...

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Autores principales:	Alexander R. Ochs, Thomas V. Karathanos, Natalia A. Trayanova, Patrick M. Boyle
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-08-01
Colección:	Frontiers in Physiology
Materias:	defibrillation optogenetics GtACR1 arrhythmia (any) computational simulation and analysis
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fphys.2021.718622/full
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