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In Vitro Studies of Flemish, Dutch, and Wild-Type β-Amyloid Provide Evidence for Two-Staged Neurotoxicity

Mutations in the β-amyloid (Aβ) sequence of the amyloid precursor protein gene (APP) present with variable disease phenotypes. While patients with the Dutch APP mutation (E693Q) have predominantly hemorrhagic strokes, Flemish APP (A692G) patients develop both strokes and Alzheimer's disease (AD). To...

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Principais autores: Samir Kumar-Singh, Ann Julliams, Rony Nuydens, Chantal Ceuterick, Christine Labeur, Sally Serneels, Krist'l Vennekens, Peter Van Osta, Hugo Geerts, Bart De Strooper, Christine Van Broeckhoven
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2002-11-01
coleção:Neurobiology of Disease
Assuntos:
Alzheimer's disease
cerebral amyloid angiopathy
tau
phosphorylation
amyloid β
amyloid precursor protein
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996102905292
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